This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. The risk may be greater if you smoke. Alitretinoin Systemic: CYP3A4 Inhibitors Strong may increase the serum concentration of Alitretinoin Systemic. Management: Consider reducing the alitretinoin dose to 10 mg when used together with strong CYP3A4 inhibitors.
Immunologic side effects have included immune reconstitution syndrome. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Silodosin: CYP3A4 Inhibitors Strong may increase the serum concentration of Silodosin. CRIXIVAN, an Antiretroviral Pregnancy Registry has been established. Administration with a substantial meal 48.
If you take Crixivan with SUSTIVA, check with your doctor. Agitation, bruxism, dream abnormality, dysesthesia, fasciculation, hypesthesia, neuralgia, peripheral neuropathy, tremor, vertigo, epidural lipomatosis, sensory loss, syncope, and peripheral paresthesia have also been reported. Oral paresthesia has been reported during postmarketing experience. Puro V, Soldani F, De Carli G, Lazarevic Z, Mattioli F, Ippolito G "Drug-induced aminotransferase alterations during antiretroviral HIV post-exposure prophylaxis. Corticosteroids Orally Inhaled: CYP3A4 Inhibitors Strong may increase the serum concentration of Corticosteroids Orally Inhaled. Management: Orally inhaled fluticasone propionate with a strong CYP3A4 inhibitor is not recommended. Exceptions: Beclomethasone Oral Inhalation; Triamcinolone Systemic.
Upper limit of the normal range. Babesiosis off-label use: Oral: 750 mg twice daily with azithromycin for 7 to 10 days; Note: Relapsing infection may require at least 6 weeks of therapy Krauss 2000; Vannier 2012. Clinical studies of Crixivan did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function and of concomitant disease or other drug therapy. Simeprevir: Protease Inhibitors may increase the serum concentration of Simeprevir. Simeprevir may increase the serum concentration of Protease Inhibitors.
Apixaban: CYP3A4 Inhibitors Strong may increase the serum concentration of Apixaban. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Public Health Service Centers for Disease Control and Prevention that HIV-infected mothers not breast-feed their infants to avoid risking postnatal transmission of HIV. SU for 2 months or greater. Patients should be informed that redistribution or accumulation of body fat may occur in patients receiving antiretroviral therapy and that the cause and long-term health effects of these conditions are not known at this time. Keep Crixivan capsules dry by leaving the small desiccant in the bottle. Keep the bottle closed. Does not inhibit CYP1A2, 2C9, 2E1, or 2B6. Your doctor may want to run some blood tests to see if your HIV therapy is still working. Many other prescription and nonprescription medicines eg, used for aches or pain, allergies, asthma or other lung or breathing problems, blood thinning, blood vessel problems, cancer, Cushing syndrome, cystic fibrosis, depression or other mental or mood problems, diabetes, erectile dysfunction, gout, high blood pressure, high cholesterol, HIV infection, immune suppression, infections, inflammation, insomnia, irregular heartbeat or other heart problems, migraine headaches, narcotic addiction, nausea or vomiting, overactive bladder, PAH, seizures, stomach or bowel problems multivitamin products, and herbal or dietary supplements eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort may interact with indinavir.
Check with your pharmacist about how to dispose of unused medicine. AUC or peak or trough plasma concentrations. Do not keep outdated medicine or medicine no longer needed. H2-Antagonists: May decrease the serum concentration of Indinavir. Alosetron is used to treat severe, chronic irritable bowel syndrome IBS in women who have had diarrhea as the main symptom for at least 6 months. Alosetron should be used only in women who have tried other IBS treatments without success. Alosetron has not been shown to be effective in men with IBS. Dabrafenib: CYP3A4 Inhibitors Strong may increase the serum concentration of Dabrafenib. Valbenazine: CYP3A4 Inhibitors Strong may increase the serum concentration of Valbenazine. Management: Reduce the valbenazine dose to 40 mg daily when combined with strong CYP3A4 inhibitors. Talk to your doctor about using trazodone safely. The optimal dosing regimen for use of indinavir in pregnant patients has not been established. A Crixivan dose of 800 mg every 8 hours with zidovudine 200 mg every 8 hours and lamivudine 150 mg twice a day has been studied in 16 HIV-infected pregnant patients at 14 to 28 weeks of gestation at enrollment study PACTG 358. Take this medicine with a full glass of water. Prezista darunavir US prescribing information. Tibotec Inc. CYP3A4 inhibitor. Avoid concurrent use in patients with impaired hepatic or renal function. MEPRON, 3 reported rash 4%. Rash was not severe in any subject. Budesonide Topical: CYP3A4 Inhibitors Strong may increase the serum concentration of Budesonide Topical. Management: Per US prescribing information, avoid this combination. Canadian product labeling does not recommend strict avoidance. If combined, monitor for excessive glucocorticoid effects as budesonide exposure may be increased. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Take this medication by as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Swallow this medication whole with a glass of water. Do not crush or chew the tablets. atrovent
FDA Public Health Advisory. 2000 Feb 10. From FDA website. Single dose unless otherwise noted. Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy, including Crixivan. Flynn TE, Bricker LA "Myocardial infarction in HIV-infected men receiving protease inhibitors. Boubaker K, Sudre P, Bally F, Vogel G, Meuwly JY, Glauser MP, Telenti A "Changes in renal function associated with indinavir. What are the possible side effects of ZERIT? Following single oral dose. Impact of Antiretroviral Therapy. What other drugs will affect alosetron Lotronex? Take this medication by mouth with a full glass of water 8 ounces or 240 milliliters on an empty stomach at least 1 hour before or 2 hours after food usually 3 times daily or as directed by your doctor. If upset stomach occurs, you may take it with other liquids such as non-fat milk, apple juice, coffee, tea or with a light meal such as dry toast with jelly, corn flakes with non-fat milk and sugar. Avoid taking this medication with a meal high in calories, fat, and protein since this may decrease its effect. If you are directed to take ritonavir with this medication, take them both at the same times. August 1994. MMWR Morb Mortal Wkly Rep. Gajewski LK, Grimone AJ, Melbourne KM, Vanscoy GJ "Characterization of rash with indinavir in a national patient cohort. Many drugs can interact with indinavir. Not all possible interactions are listed here. ONGLYZA can be taken with or without food. HIV protease inhibitor. J Med Chem. harr.info repaglinide
May result in an increase in PDE5 inhibitor-associated adverse events, including hypotension, syncope, visual disturbances, and priapism. Alosetron may also be used for purposes not listed in this medication guide. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking indinavir, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. If possible, protease inhibitors should be used in combination with 2 nucleoside analogs since triple therapy appears to be the most potent antiretroviral combination available. However, one nucleoside plus a protease inhibitor may be effective if drug intolerance prevents the use of triple therapy. The study was terminated after a planned interim analysis, resulting in a median follow-up of 38 weeks and a maximum follow-up of 52 weeks. Taking marijuana might decrease the effects of theophylline. But there isn't enough information to know if this is a big concern. Rodwell GEJ, Maurer TA, Barger TG "Fat redistribution in HIV disease. Particular caution should be used when prescribing sildenafil, tadalafil, or vardenafil in patients receiving indinavir. Inhibits replication of HIV-1 and HIV-2 by interfering with HIV protease. Ribociclib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ribociclib. Management: Avoid use of ribociclib with strong CYP3A4 inhibitors when possible; if combined use cannot be avoided, reduce ribociclib dose to 400 mg once daily. MedroxyPROGESTERone: CYP3A4 Inhibitors Strong may increase the serum concentration of MedroxyPROGESTERone. The atorvastatin and rosuvastatin doses should be carefully titrated; use the lowest dose necessary with careful monitoring during treatment with Crixivan.
MEPRON suspension or aerosolized pentamidine. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Arthralgia has been reported during postmarketing experience. There were 798 deaths in the SAVOR trial. Repaglinide: CYP3A4 Inhibitors Strong may increase the serum concentration of Repaglinide. Management: The addition of a CYP2C8 inhibitor to this drug combination may substantially increase the magnitude of increase in repaglinide exposure. Indinavir is not a cure for HIV infection. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Dosage adjustment recommended in patients with hepatic impairment due to cirrhosis. 1 See Hepatic Impairment under Dosage and Administration. Midazolam is extensively metabolized by CYP3A4. Co-administration with Crixivan with or without ritonavir may cause a large increase in the concentration of this benzodiazepine. No drug interaction study has been performed for the co-administration of Crixivan with benzodiazepines. Based on data from other CYP3A4 inhibitors, plasma concentrations of midazolam are expected to be significantly higher when midazolam is given orally. Therefore Crixivan should not be co-administered with orally administered midazolam see whereas caution should be used with co-administration of Crixivan and parenteral midazolam. Data from concomitant use of parenteral midazolam with other protease inhibitors suggest a possible 3-4 fold increase in midazolam plasma levels. Temsirolimus: CYP3A4 Inhibitors Strong may increase the serum concentration of Temsirolimus. Fluticasone Oral Inhalation: CYP3A4 Inhibitors Strong may increase the serum concentration of Fluticasone Oral Inhalation. Management: Use of orally inhaled fluticasone propionate with strong CYP3A4 inhibitors is not recommended. Use of orally inhaled fluticasone furoate with strong CYP3A4 inhibitors should be done with caution. Monitor patients using such a combination more closely. Appropriate studies have not been performed on the relationship of age to the effects of indinavir in the pediatric population. Safety and efficacy have not been established. Carr A, Samaras K, Chisholm DJ et al. Pathogenesis of HIV-1-protease inhibitor- associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. Lancet. What should I discuss with my healthcare provider before taking Crixivan indinavir? Crixivan does not cure HIV infection or AIDS and you may continue to experience illnesses associated with HIV-1 infection, including opportunistic infections. You should remain under the care of a doctor when using Crixivan. buy now metronidazole otc
Nilotinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Nilotinib. The appropriate doses for this combination, with respect to efficacy and safety, have not been established. Preliminary clinical data suggest that the incidence of nephrolithiasis is higher in patients receiving indinavir in combination with ritonavir than those receiving CRIXIVAN 800 mg q8h. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Pharmacokinetics of indinavir appear to be comparable in Caucasians and Blacks based on pharmacokinetic studies including 42 Caucasians 26 HIV-positive and 16 Blacks 4 HIV-positive. This medicine is available only with your doctor's prescription. Keep taking indinavir for the full time of treatment, even if you begin to feel better. CYP1A2, 2B6, 2C9, or 3A4. Alosetron: CYP3A4 Inhibitors Strong may increase the serum concentration of Alosetron. Levomilnacipran: CYP3A4 Inhibitors Strong may increase the serum concentration of Levomilnacipran. cheapest cyproheptadine order now shopping
Indinavir is metabolized by and inhibits CYP450 3A4 isoenzymes and may potentially interact with many drugs. Tacrolimus Topical: Protease Inhibitors may decrease the metabolism of Tacrolimus Topical. Contact your doctor if you miss any menstrual periods so that the cause may be determined. Lomitapide: CYP3A4 Inhibitors Strong may increase the serum concentration of Lomitapide. Szczech LA "Hypertension and medication-related renal dysfunction in the HIV-infected patient. What should I discuss with my healthcare provider before taking indinavir? However, atovaquone is not appreciably renally excreted. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Indinavir capsules are sensitive to moisture. Patients should be instructed to store and use the drug from the original container and keep the desiccant in the bottle. Gagnon RF, Alli AI, Edwardes MD, Watters AK, Tsoukas CM "Low urine pH is associated with reduced indinavir crystalluria in indinavir-treated HIV-infected individuals.
Consider alternative antiretroviral therapy to avoid increases in quetiapine drug exposures. Gerberding JL, Henderson DK. Management of occupational exposures to bloodborne pathogens: hepatitis B virus, hepatitis C virus, and human immunodeficiency virus. Clin Infect Dis. Do not take other medicines unless they have been discussed with your doctor. Atovaquone undergoes enterohepatic cycling and primarily hepatic excretion. Use caution in patients with severe impairment; monitor closely. Disulfiram Antabuse might interact with marijuana. Taking marijuana along with Disulfiram can cause agitation, trouble sleeping, and irritability. Bristol-Myers Squibb. Videx didanosine prescribing information. Princeton, NJ; 2009 Jun. Your doctor may want to run some blood test on you. Let your doctor know if you have any yellowing of the eyes or skin or any abdominal pain. Halofantrine: CYP3A4 Inhibitors Strong may increase the serum concentration of Halofantrine. ZERIT may be taken with or without food. price varenicline ulotka
Crixivan must be taken at intervals of 8 hours. For optimal absorption, Crixivan should be administered without food but with water 1 hour before or 2 hours after a meal. Both Crixivan and atazanavir are associated with indirect unconjugated hyperbilirubinemia. Combinations of these drugs have not been studied and coadministration of Crixivan and atazanavir is not recommended. Taking marijuana with fluoxetine Prozac might cause you to feel irritated, nervous, jittery, and excited. Doctors call this hypomania. Pimecrolimus: CYP3A4 Inhibitors Strong may decrease the metabolism of Pimecrolimus. Mean change from baseline is adjusted for baseline value. You could get pregnant if you have sex in the 7 days after you miss pills. Centers for Disease Control and Prevention. Notice to readers: updated guidelines for the use of rifabutin or rifampin for the treatment and prevention of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibitors. MMWR Morb Mortal Wkly Rep. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Advise patients that effective antiretroviral regimens can decrease HIV concentrations in blood and genital secretions and strict adherence to such regimens in conjunction with risk-reduction measures may decrease, but cannot absolutely eliminate, the risk of secondary transmission of HIV to others. Which drugs or supplements interact with indinavir? minocycline
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Eplerenone: CYP3A4 Inhibitors Strong may increase the serum concentration of Eplerenone. Palbociclib: CYP3A4 Inhibitors Strong may increase the serum concentration of Palbociclib. Crixivan at the recommended dose in clinical trials with a median follow-up of 47 weeks range: 1 day to 242 weeks; 2238 patient-years follow-up. The cumulative frequency of nephrolithiasis events increases with duration of exposure to Crixivan; however, the risk over time remains relatively constant.
Bouscarat F, Bouchard C, Bouhour D "Paronychia and pyogenic granuloma of the great toes in patients treated with indinavir. Tamsulosin: CYP3A4 Inhibitors Strong may increase the serum concentration of Tamsulosin. Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. St. John's wort is not recommended.
TZD at their pre-study dose. If it is almost time for your next dose, skip the missed dose. May lead to loss of virologic response and possible resistance to Crixivan or to the class of protease inhibitors or other coadministered antiretroviral agents. ONGLYZA 5 mg group and 5 units for the placebo group.
Do NOT take more than the recommended dose, change the dose, or stop taking indinavir without checking with your doctor. QuiNIDine: Indinavir may increase the serum concentration of QuiNIDine. Indinavir pharmacokinetic parameters in these women were compared to those in HIV seropositive men pooled historical control data. The dosage of Crixivan should be reduced to 600 mg every 8 hours in patients with mild-to-moderate hepatic insufficiency due to cirrhosis. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.